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Trial purpose
The goal of this study is to evaluate the efficacy and safety of pembrolizumab plus belzutifan plus lenvatinib or pembrolizumab/quavonlimab plus lenvatinib versus pembrolizumab plus lenvatinib as first-line treatment in participants with advanced clear cell renal cell carcinoma (ccRCC).
The primary hypotheses are (1) pembrolizumab plus belzutifan plus lenvatinib is superior to pembrolizumab plus lenvatinib with respect to progression-free survival (PFS) and overall survival (OS), in advanced ccRCC participants; and (2) pembrolizumab/quavonlimab plus lenvatinib is superior to pembrolizumab plus lenvatinib with respect to PFS and OS, in advanced ccRCC participants.
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NATIONAL TRIAL REFERENCE NUMBER | NCT04736706 |
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Conditions | Carcinoma, Renal Cell |
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Age Range | 18+ |
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Sex | All |
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Current trial phase | 1 |
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Trial start and end dates | [04-14-2021] [10-29-2026] |
About the trial
Eligibility
Only a qualified healthcare professional can determine if you are eligible to take part in a clinical trial. However, this information may be useful in starting a conversation with your doctor.
Conditions
Carcinoma, Renal Cell
All patients who enroll in the trial will receive medication while on the study.
33% will receive pembrolizumab plus MK-6482 and lenvatinib
33% will receive MK-1308A (pembrolizumab with MK-1308) plus lenvatinib
33% will receive pembrolizumab plus lenvatinib
*A computer will decide which group you are put in. You have a 1 in 3 chance of getting put in each group. You, your trial doctor, and the trial staff will know what you are getting.
Phase 3
In Phase 3 trials, researchers try to find out if a treatment works in a large number of people, usually about 1,000 to 5,000 participants who have the health condition the treatment is intended to treat. In vaccine trials, the participants may be healthy or have diseases or conditions. Phase 3 trials may happen in a doctor’s office, a clinic, or a hospital.
Trial locations (0)
Locations shown may have changed in some cases. Please call the number listed in the location results to confirm the nearest trial site. Talk with a trial site member for more information.