A Study of Intismeran Autogene Plus Pembrolizumab Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer

Trial Information
Eligibility
Locations
Next steps

Recruiting

Trial Purpose

The goal of this study is to evaluate intismeran autogene plus pembrolizumab versus placebo plus pembrolizumab for the adjuvant treatment of margin negative, completely resected Stage II, IIIA, IIIB (with nodal involvement [N2]) non-small cell lung cancer (NSCLC). The primary hypothesis is that intismeran autogene plus pembrolizumab is superior to placebo plus pembrolizumab with respect to disease-free survival (DFS) as assessed by the investigator.

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	National Trial Reference Number	NCT06077760
	MSD Protocol ID
	Conditions	Non-small Cell Lung Cancer
	Age Range	18+
	Sex	ALL
	Trial Phase	3
	Start Date End Date	2023-12-06 2035-12-21

Study Details

Patient Participation

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Conditions

Non-small Cell Lung Cancer

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Trial Phase 3

In Phase 3 trials, researchers try to find out if a treatment works in a large number of people, usually about 1,000 to 5,000 participants who have the health condition the treatment is intended to treat. In vaccine trials, the participants may be healthy or have diseases or conditions. Phase 3 trials may happen in a doctor’s office, a clinic, or a hospital.

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Trial Locations

Locations shown may have changed in some cases. Please call the number listed in the location results to confirm the nearest trial site. Talk with a trial site member for more information.

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The investigational treatment that is being studied
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Clinicaltrials.gov Identifier

NCT06077760

When you talk with your doctor or clinical trial team member, please have the trial identifier number or the EudraCT number available.