A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab in Second-line + Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma .

Trial Information
Eligibility
Locations
Next steps

Recruiting

Trial Purpose

The purpose of this study is to assess the safety and tolerability and to confirm the dose of nemtabrutinib in combination with venetoclax in participants with R/R CLL/SLL. The primary study hypotheses are that the combination of nemtabrutinib plus venetoclax is superior to VR with respect to progression-free survival (PFS) per 2018 International Workshop on Chronic Lymphocytic Leukemia (iwCLL) criteria as assessed by blinded independent central review (BICR).

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	National Trial Reference Number	NCT05947851
	MSD Protocol ID	MK-1026-010
	Conditions	CLL, Leukemia, Chronic Lymphocytic, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Small Lymphocytic, SLL, Small-Cell Lymphoma
	Age Range	18+
	Sex	ALL
	Trial Phase	3
	Start Date End Date	2023-08-08 2035-07-01

Study Details

Patient Participation

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Conditions

CLL, Leukemia, Chronic Lymphocytic, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Small Lymphocytic, SLL, Small-Cell Lymphoma

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Trial Phase 3

In Phase 3 trials, researchers try to find out if a treatment works in a large number of people, usually about 1,000 to 5,000 participants who have the health condition the treatment is intended to treat. In vaccine trials, the participants may be healthy or have diseases or conditions. Phase 3 trials may happen in a doctor’s office, a clinic, or a hospital.

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Trial Locations

Locations shown may have changed in some cases. Please call the number listed in the location results to confirm the nearest trial site. Talk with a trial site member for more information.

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Clinicaltrials.gov Identifier

NCT05947851

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