A Study to Evaluate Zilovertamab Vedotin Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Participants With Previously Untreated DLBCL

Trial Information
Eligibility
Locations
Next steps

Recruiting

Trial Purpose

The purpose of this study is to evaluate if zilovertamab vedotin with standard treatment can help people live longer without the cancer growing or spreading than people who receive standard treatment alone.

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	National Trial Reference Number	NCT06717347
	MSD Protocol ID	MK-2140-010
	Conditions	Diffuse Large B-Cell Lymphoma
	Age Range	18+
	Sex	ALL
	Trial Phase	3
	Start Date End Date	2025-01-27 2032-03-29

Study Details

Patient Participation

Only a qualified healthcare professional can determine if you are eligible to take part in a clinical trial.

Conditions

Diffuse Large B-Cell Lymphoma

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Trial Phase 3

In Phase 3 trials, researchers try to find out if a treatment works in a large number of people, usually about 1,000 to 5,000 participants who have the health condition the treatment is intended to treat. In vaccine trials, the participants may be healthy or have diseases or conditions. Phase 3 trials may happen in a doctor’s office, a clinic, or a hospital.

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Trial Locations

Locations shown may have changed in some cases. Please call the number listed in the location results to confirm the nearest trial site. Talk with a trial site member for more information.

What can you do next?

If you think this clinical trial might be a good fir and you are interested in taking part, take the next step to see if you are eligible.

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Taking part in a clinical trial is an important decision

If you are considering joining a clinical trial, first learn as much as you can about:

The investigational treatment that is being studied
What the risks and possible benefits are for participants

Talk to your doctor about the clinical trial before you decide to join.

Read our “What to Consider” page for more questions to ask and think about

Clinicaltrials.gov Identifier

NCT06717347

When you talk with your doctor or clinical trial team member, please have the trial identifier number or the EudraCT number available.