A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer

Trial Information
Eligibility
Locations
Next steps

Recruiting

Trial Purpose

Researchers are investigating new treatments for untreated advanced non-small cell lung cancer (NSCLC), which is the most common form of lung cancer and lung cancer that has spread beyond surgical removal. Standard treatments include immunotherapy, such as pembrolizumab, and chemotherapy. This study aims to determine the effectiveness of adding other treatments, including the human epidermal growth factor receptor 3-directed antibody-drug conjugate (HER3-DXd) patritumab deruxtecan, to pembrolizumab, with or without chemotherapy. The primary goals are to assess safety and efficacy of the treatments.

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	National Trial Reference Number	NCT06731907
	MSD Protocol ID	MK-3475-01G
	Conditions	Non-small Cell Lung Cancer
	Age Range	18+
	Sex	ALL
	Trial Phase	2
	Start Date End Date	2025-03-30 2032-03-12

Study Details

Patient Participation

Only a qualified healthcare professional can determine if you are eligible to take part in a clinical trial.

Conditions

Non-small Cell Lung Cancer

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Trial Phase 2

In Phase 2 trials, researchers try to find out if a treatment works in about 100 to 500 participants – usually people who have the health condition the treatment is intended to treat. In vaccine trials, the participants are usually healthy. Phase 2 trials may happen in a doctor’s office, a clinic, or a hospital.

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Trial Locations

Locations shown may have changed in some cases. Please call the number listed in the location results to confirm the nearest trial site. Talk with a trial site member for more information.

What can you do next?

If you think this clinical trial might be a good fir and you are interested in taking part, take the next step to see if you are eligible.

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The investigational treatment that is being studied
What the risks and possible benefits are for participants

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Clinicaltrials.gov Identifier

NCT06731907

When you talk with your doctor or clinical trial team member, please have the trial identifier number or the EudraCT number available.